Selected Publications

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Weir NR, Kamber RA, Martenson JS, Denic V. (2017). The AAA protein Msp1 mediates clearance of excess tail-anchored proteins from the peroxisomal membrane. Elife; Sep 14;6. pii: e28507. doi: 10.7554/eLife.28507. [Epub ahead of print]

Zalisko BE, Chan C, Denic V, Rock RS, Keenan RJ. (2017). Tail-Anchored Protein Insertion by a Single Get1/2 Heterodimer. Cell Reports; Sep 5;20(10):2287-2293.

Eapen VV, Waterman DP, Bernard A, Schiffmann N, Sayas E, Kamber R, Lemos B, Memisoglu G, Ang J, Mazella A, Chuartzman SG, Loewith RJ, Schuldiner M, Denic V, Klionsky DJ, Haber JE. (2017). A pathway of targeted autophagy is induced by DNA damage in budding yeast. Proceedings of the National Academy of Sciences of the United States of America; Feb 14;114(7):E1158-E1167.

Solís EJ, Pandey JP, Zheng X, Jin DX, Gupta PB, Airoldi EM, Pincus D, Denic V. (2016). Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis. Molecular Cell; Jul 7;63(1):60-71.

Kamber R., Shoemaker C., Denic V. (2015). A molecular switch for selective autophagosome formation. Autophagy; Nov 2;11(11):2132-2133.

Denic V. (2015). Advice to a young scientist (by someone who doesn’t know how to give it). Molecular Biology of the CellNov 1;26(21):3681-3.

Kamber R., Shoemaker C., Denic V. (2015). Receptor-Bound Target of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase. Molecular Cell; Aug 6;59(3):372-81.

Wang F., Chan C., Weir N. R., Denic V. (2014). The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature; Aug 28;512(7515):441-4.

Denic V, Dötsch V, Sinning I. (2013). ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway. Cold Spring Harb Perspect Biol; Aug 1;5(8):a013334.

Denic V. (2012). A portrait of the GET pathway as a surprisingly complicated young man. Trends in Biochemical Sciences; Oct;37(10):411-7.

Wang F., Whynot A., Tung M., Denic V. (2011). The Mechanism of Tail-Anchored Protein Insertion into the ER Membrane. Molecular Cell; 43, 738-750.

Stefer S., Reitz S., Wang F., Wild K., Pang YY., Schwarz D, Bomke J, Hein C, Löhr F, Bernhard F, Denic V*., Dötsch V*., Sinning I*. Structural Basis for Tail-Anchored Membrane Protein Biogenesis by the Get3-Receptor Complex. Science; 2011 Aug. 5; 333(6043): 758-762.   *co-corresponding authors.

Denic V. (2011). No Country for Old Misfolded Glycoproteins. Molecular Cell; 42, 715-717.

Wang F., Brown E. C., Mak G., Zhuang J., Denic V. (2010). A Chaperone Cascade Sorts Proteins for Post-Translational Membrane Insertion into the ER. Molecular Cell; 40, 159-171

 

Other publications (in chronological order):

1.  Bhamidipati, A., Denic, V., Quan, E. M., Weissman, J. S. (2005). Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER lumen. Molecular Cell; 19, 741-751.

2.  Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., et al. (2005). Exploration of the Function and Organization of the Yeast Early Secretory Pathway through an Epistatic Miniarray Profile. Cell; 123, 507-519.

3.  Denic V., Quan E. M., Weissman, J. S. (2006). A Luminal Surveillance Complex that Selects Misfolded Glycoproteins for Endoplasmic Reticulum-Associated Degradation. Cell; 126, 349-359.

4.  Denic V., Weissman J. S. (2007). A Molecular Caliper Mechanism for Determining Very Long-Chain Fatty Acid Length. Cell; 130, 663-677.

5.  Schuldiner M.,* Metz J., Schmid V., Denic V.* et al. (2008). The GET Complex Mediates Insertion of Tail-Anchored Proteins into the ER. Cell; 134, 634-645. (*co-first author)

6.  Quan, E. M.,  Kamiya, Y., Kamiya, D., Denic, V.,  Weibezahn, J., Kato, K., Weissman, J. S. (2008). Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation. Molecular Cell; 32, 870-877.

7.  Jonikas, M. C., Collins, S. R., Denic, V., Oh, E., Quan, E. M., Schmid, V., Weibezahn, J., Schwappach, B., Walter, P., Weissman, J. S., Schuldiner, M. The Anatomy of a Cellular Folding Compartment. Science; 2009 Mar 27; 323(5922): 1693-7.

8. Hu J., Li J., Qian X., Denic V., Sha B. The Crystal Structures of Yeast Get3 Suggest a Mechanism for Tail-Anchored Protein Membrane Insertion PLoS One. 2009 Nov. 30; 4(11)e8061.