Denic Laboratory
Denic Laboratory
Denic Laboratory

Selective Autophagy

Selective autophagy is a protein targeting process that captures large unwanted structures into double-membrane transport vesicles called autophagosomes, which deliver the trapped targets to the lysosome for degradation (Figure 1A). Over the past […]


Protein Homeostasis During Replicative Aging in Budding Yeast

Budding yeast cells divide asymmetrically: a larger mother cell buds off a smaller daughter cell at the end of each cell cycle (Figure 1). After an average of 20-30 cell […]

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The Biogenesis of Tail-Anchored Proteins

The specialized functions of intracellular membrane compartments (organelles) depend on their unique protein compositions. The protein delivery systems that direct proteins to organelles are set in motion by the recognition […]


Wow! I can’t believe over a year has passed with nothing to say. Perhaps David Byrne was right: heaven IS in fact a place where nothing ever happens. Alas, I […]

Inaugural Blogging

Captain’s blog 061113: Never thought this moment would come. Since the inception of the new lab website several blog-worthy events have transpired. Charlene Chan (Chemical Biology PhD Program) has joined […]